› 7rtz

X-ray diffraction
2.1Å resolution

X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 14-40

Released:
DOI: 10.2210/pdb7rtz/pdb
PDB entry 7rtz coloured by chain, front view.
PDB entry 7rtz coloured by chain, side view.
PDB entry 7rtz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A beta-Barrel-Like Tetramer Formed by a beta-Hairpin Derived From A beta
Samdin TD, Jones CR, Guaglianone G, Kreutzer AG, Freites JA, Wierzbicki M, Nowick JS
Chem Sci (2023)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(42) Chains: A, B
Molecule details ›
Chains: A, B
Length: 24 amino acids
Theoretical weight: 2.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 682-711; Coverage: 3%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
2 modified residues:
Ligand ORN 4 x ORN
Ligand SAR 2 x SAR

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P41212
Unit cell:
a: 44.327Å b: 44.327Å c: 64.427Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.266 0.263 0.293
Expression system: Not provided

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