› 7ru6

Electron Microscopy
4.4Å resolution

Cryo-EM structure of the HIV-1 restriction factor human SERINC3

Released:
DOI: 10.2210/pdb7ru6/pdb
PDB entry 7ru6 coloured by chain, front view.
PDB entry 7ru6 coloured by chain, side view.
PDB entry 7ru6 coloured by chain, top view.
Source organisms:
Primary publication:
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.
Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M
OpenAccess logo Nat Commun 14 4368 (2023)
PMID: 37474505
Related structures: EMD-24698

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226214 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine incorporator 3 Chain: A
Molecule details ›
Chain: A
Length: 494 amino acids
Theoretical weight: 55.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13530 (Residues: 1-473; Coverage: 100%)
Gene names: DIFF33, SBBI99, SERINC3, TDE1
Sequence domains: Serine incorporator (Serinc)
SiA Chain: L
Molecule details ›
Chain: L
Length: 241 amino acids
Theoretical weight: 25.62 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-24698
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

Quick links

Citations

1 citations in other articles

The Antiviral Factor SERINC5 Impairs the Expression of Non-Self-DNA.
Shi et al. (2023)

1 mention without citation

Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.
Leonhardt et al. (2023)