› 7rv8

X-ray diffraction
1.25Å resolution

Crystal structure of the BCL6 BTB domain in complex with OICR-10268

Released:
DOI: 10.2210/pdb7rv8/pdb
PDB entry 7rv8 coloured by chain, front view.
PDB entry 7rv8 coloured by chain, side view.
PDB entry 7rv8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kuntz DA, Prive GG

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
B-cell lymphoma 6 protein Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P41182 (Residues: 5-129; Coverage: 18%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain

Ligands and Environments

2 bound ligands:
Ligand 7ST 1 x 7ST
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 30.768Å b: 72.566Å c: 55.128Å
α: 90° β: 105.85° γ: 90°
R-values:
R R work R free
0.138 0.136 0.162
Expression system: Escherichia coli BL21

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