› 7rxa

Electron Microscopy
3.08Å resolution

afTMEM16 DE/AA mutant in C14 lipid nanodiscs in the presence of Ca2+

Released:
DOI: 10.2210/pdb7rxa/pdb
PDB entry 7rxa coloured by chain, front view.
PDB entry 7rxa coloured by chain, side view.
PDB entry 7rxa coloured by chain, top view.
Source organism: Aspergillus fumigatus A1163
Primary publication:
TMEM16 scramblases thin the membrane to enable lipid scrambling.
Falzone ME, Feng Z, Alvarenga OE, Pan Y, Lee B, Cheng X, Fortea E, Scheuring S, Accardi A
OpenAccess logo Nat Commun 13 2604 (2022)
PMID: 35562175
Related structures: EMD-24726

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175798 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasma membrane channel protein (Aqy1) Chains: A, B
Molecule details ›
Chains: A, B
Length: 735 amino acids
Theoretical weight: 84.51 KDa
Source organism: Aspergillus fumigatus A1163
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q4WA18 (Residues: 1-735; Coverage: 100%)
Gene name: AFUA_4G02970
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PGW 8 x PGW
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.08Å
Relevant EMDB volumes: EMD-24726
Expression system: Saccharomyces cerevisiae

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Citations

3 review citations

Regulation of membrane protein structure and function by their lipid nano-environment.
Levental et al. (2023)
2 more