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S. CEREVISIAE CYP51 I471T MUTANT COMPLEXED WITH ITRACONAZOLE

Source organism: Saccharomyces cerevisiae YJM789
Biochemical function: metal ion binding
Biological process: sterol biosynthetic process
Cellular component: membrane

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EC 1.14.14.154: Sterol 14-alpha-demethylase

Reaction catalysed:
(1a) a 14-alpha-methylsteroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 14-alpha-hydroxysteroid + [oxidized NADPH--hemoprotein reductase] + H(2)O
Systematic name:
Sterol,[reduced NADPH--hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving)
Alternative Name(s):
  • CYP51
  • Cytochrome P450 51
  • ERG11
  • Lanosterol 14-alpha-demethylase
  • Lanosterol 14-demethylase
  • Obtusufoliol 14-demethylase
  • Sterol 14-demethylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00067
Domain description: Cytochrome P450
Occurring in:
  1. Lanosterol 14-alpha demethylase CYP51
The deposited structure of PDB entry 7rya contains 1 copy of Pfam domain PF00067 (Cytochrome P450) in Lanosterol 14-alpha demethylase CYP51. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002403
Domain description: Cytochrome P450, E-class, group IV
Occurring in:
  1. Lanosterol 14-alpha demethylase CYP51
IPR001128
Domain description: Cytochrome P450
Occurring in:
  1. Lanosterol 14-alpha demethylase CYP51
IPR036396
Domain description: Cytochrome P450 superfamily
Occurring in:
  1. Lanosterol 14-alpha demethylase CYP51

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