7ryc

Electron Microscopy
2.9Å resolution

Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-275982 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Oxytocin Chain: L
Molecule details ›
Chain: L
Length: 10 amino acids
Theoretical weight: 1.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01178 (Residues: 20-28; Coverage: 9%)
Gene names: OT, OXT
Sequence domains: Neurohypophysial hormones, N-terminal Domain
Oxytocin receptor Chain: O
Molecule details ›
Chain: O
Length: 450 amino acids
Theoretical weight: 49.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P30559 (Residues: 1-389; Coverage: 100%)
Gene name: OXTR
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: D
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: C
scFv16 Chain: E

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-24733
Expression systems:
  • Not provided
  • Homo sapiens
  • Spodoptera frugiperda