› 7ryz

Electron Microscopy
4.15Å resolution

Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate

Released:
DOI: 10.2210/pdb7ryz/pdb
PDB entry 7ryz coloured by chain, front view.
PDB entry 7ryz coloured by chain, side view.
PDB entry 7ryz coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1L.
Klykov O, Gangwar SP, Yelshanskaya MV, Yen L, Sobolevsky AI
Mol Cell 81 4771-4783.e7 (2021)
PMID: 34678168
Related structures: EMD-24749

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1154 amino acids
Theoretical weight: 128.82 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Best match: P19491-2 (Residues: 25-847)
Gene names: GluA2, Glur2, Gria2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand QUS 4 x QUS
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.15Å
Relevant EMDB volumes: EMD-24749
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Tetraspanins as Potential Modulators of Glutamatergic Synaptic Function.
Becic et al. (2021)
1 more

3 mentions without citation

Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1L.
Klykov et al. (2021)
2 more