› 7rzg

Electron Microscopy
4.1Å resolution

Insulin Degrading Enzyme O/pO

Released:
DOI: 10.2210/pdb7rzg/pdb
PDB entry 7rzg coloured by chain, front view.
PDB entry 7rzg coloured by chain, side view.
PDB entry 7rzg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mancl JM, Liang WG, Tang WJ
Related structures: EMD-24759

Function and Biology Details

Reaction catalysed: 
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147045 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-degrading enzyme Chains: A, B
Molecule details ›
Chains: A, B
Length: 1011 amino acids
Theoretical weight: 117.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14735 (Residues: 1-1011; Coverage: 99%)
Gene name: IDE
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-24759
Expression system: Escherichia coli

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