› 7rzy

Electron Microscopy
3.5Å resolution

CryoEM structure of Vibrio cholerae transposon Tn6677 AAA+ ATPase TnsC

Released:
DOI: 10.2210/pdb7rzy/pdb
PDB entry 7rzy coloured by chain, front view.
PDB entry 7rzy coloured by chain, side view.
PDB entry 7rzy coloured by chain, top view.
Source organism: Vibrio cholerae
Primary publication:
Selective TnsC recruitment enhances the fidelity of RNA-guided transposition.
Hoffmann FT, Kim M, Beh LY, Wang J, Vo PLH, Gelsinger DR, George JT, Acree C, Mohabir JT, Fernández IS, Sternberg SH
Nature (2022)
PMID: 36002573
Related structures: EMD-24783

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168752 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tn6677 Vibrio cholerae transposon TnsC (VchTnsC) Chains: 1, 2, 3, 4, 5, 6, 7
Molecule details ›
Chains: 1, 2, 3, 4, 5, 6, 7
Length: 330 amino acids
Theoretical weight: 37.6 KDa
Source organism: Vibrio cholerae
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand ATP 7 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-24783
Expression system: Escherichia coli

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Citations

4 review citations

Non-viral chimeric antigen receptor (CAR) T cells going viral.
Balke-Want et al. (2023)
3 more

1 mention without citation

Selective TnsC recruitment enhances the fidelity of RNA-guided transposition.
Hoffmann et al. (2022)