› 7s0d

Electron Microscopy
3.5Å resolution

Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody N-612-014

Released:
DOI: 10.2210/pdb7s0d/pdb
PDB entry 7s0d coloured by chain, front view.
PDB entry 7s0d coloured by chain, side view.
PDB entry 7s0d coloured by chain, top view.
Source organisms:
Primary publication:
Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display.
Tanaka S, Olson CA, Barnes CO, Higashide W, Gonzalez M, Taft J, Richardson A, Martin-Fernandez M, Bogunovic D, Gnanapragasam PNP, Bjorkman PJ, Spilman P, Niazi K, Rabizadeh S, Soon-Shiong P
OpenAccess logo Cell Rep 38 110348 (2022)
PMID: 35114110
Related structures: EMD-24787

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210299 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1271 amino acids
Theoretical weight: 141.16 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1213; Coverage: 95%)
Gene names: 2, S
Sequence domains:
N-612-014 Fab Heavy Chain Chains: H, M, O
Molecule details ›
Chains: H, M, O
Length: 228 amino acids
Theoretical weight: 24.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
N-612-014 Light Chain Chains: L, N, P

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-24787
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Protective neutralizing epitopes in SARS-CoV-2.
Liu et al. (2022)
1 more

2 mentions without citation

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants.
Chi et al. (2023)
1 more