› 7s11

X-ray diffraction
2.58Å resolution

Crystal structure of Fab in complex with mouse CD96 monomer

Released:
DOI: 10.2210/pdb7s11/pdb
PDB entry 7s11 coloured by chain, front view.
PDB entry 7s11 coloured by chain, side view.
PDB entry 7s11 coloured by chain, top view.
Source organisms:
Primary publication:
Antibody blockade of CD96 by distinct molecular mechanisms.
Lee PS, Chau B, Barman I, Bee C, Jashnani A, Hogan JM, Aguilar B, Dollinger G, Rajpal A, Strop P
OpenAccess logo MAbs 13 1979800
PMID: 34595996

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212257 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
T-cell surface protein tactile Chains: C, D, E, F
Molecule details ›
Chains: C, D, E, F
Length: 122 amino acids
Theoretical weight: 13.9 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q3U0X8 (Residues: 24-138; Coverage: 20%)
Gene name: Cd96
Fab heavy chain Chains: H, I, J, K
Molecule details ›
Chains: H, I, J, K
Length: 229 amino acids
Theoretical weight: 24.47 KDa
Source organism: Rattus
Expression system: Homo sapiens
Fab light chain Chains: L, M, N, O
Molecule details ›
Chains: L, M, N, O
Length: 216 amino acids
Theoretical weight: 23.05 KDa
Source organism: Rattus
Expression system: Homo sapiens

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand SO4 6 x SO4
1 modified residue:
Ligand PCA 8 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2221
Unit cell:
a: 124.93Å b: 154.89Å c: 306Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.279
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

Application of IgG antibody titer and subtype in diagnosis and severity assessment of hemolytic disease of the newborn.
Ding et al. (2022)
1 more

4 mentions without citation

Adenosine is inherently favored as the branch-site RNA nucleotide in a structural context that resembles natural RNA splicing.
Zelin et al. (2006)
3 more