7s1u

X-ray diffraction
2.55Å resolution

Structure of human POT1C

Released:
Source organism: Homo sapiens
Primary publication:
POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance.
Comput Struct Biotechnol J 20 675-684 (2022)
PMID: 35140887

Function and Biology Details

Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-192625 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protection of telomeres protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 304 amino acids
Theoretical weight: 34.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia phage EcSzw-2
UniProt:
  • Canonical: Q9NUX5 (Residues: 331-634; Coverage: 48%)
Gene name: POT1
Sequence domains: Protection of telomeres protein 1 (POT1), C-terminal insertion domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P3221
Unit cell:
a: 162.88Å b: 162.88Å c: 63.62Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.185 0.213
Expression system: Escherichia phage EcSzw-2