› 7s47

X-ray diffraction
2Å resolution

Integrin beta5(743-774)-linker-PAK4cat(D440N/S474E)

Released:
DOI: 10.2210/pdb7s47/pdb
PDB entry 7s47 coloured by chain, front view.
PDB entry 7s47 coloured by chain, side view.
PDB entry 7s47 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Ha BH, Yigit S, Natarajan N, Morse EM, Calderwood DA, Boggon TJ
Commun Biol 5 1257- (2022)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-220466 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin beta-5; Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 43.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18084 (Residues: 743-774; Coverage: 4%)
  • Canonical: O96013 (Residues: 286-591; Coverage: 52%)
Gene names: ITGB5, KIAA1142, PAK4
Sequence domains:
Integrin beta-5 Chain: B
Molecule details ›
Chain: B
Length: 32 amino acids
Theoretical weight: 3.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18084 (Residues: 743-774; Coverage: 4%)
Gene name: ITGB5
Sequence domains: Integrin beta cytoplasmic domain

Ligands and Environments

1 bound ligand:
Ligand ANP 1 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P41212
Unit cell:
a: 62.321Å b: 62.321Å c: 178.609Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.237
Expression system: Escherichia coli

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