› 7s48

X-ray diffraction
1.9Å resolution

PAK4cat in complex with Integrin beta5 760-770 peptide

Released:
DOI: 10.2210/pdb7s48/pdb
PDB entry 7s48 coloured by chain, front view.
PDB entry 7s48 coloured by chain, side view.
PDB entry 7s48 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Ha BH, Yigit S, Natarajan N, Morse EM, Calderwood DA, Boggon TJ
Commun Biol 5 1257- (2022)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132119 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 39.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 286-591; Coverage: 52%)
  • Best match: O96013-2 (Residues: 109-426)
Gene names: KIAA1142, PAK4
Sequence domains: Protein kinase domain
Integrin beta-5 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P18084 (Residues: 760-770; Coverage: 1%)
Gene name: ITGB5

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P41212
Unit cell:
a: 61.735Å b: 61.735Å c: 179.987Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.222
Expression systems:
  • Escherichia coli
  • Not provided

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