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CryoEM structure of Methylococcus capsulatus (Bath) pMMO in a native lipid nanodisc at 2.16 Angstrom resolution

Source organism: Methylococcus capsulatus str. Bath
Biochemical function: monooxygenase activity
Biological process: not assigned
Cellular component: membrane

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EC 1.14.18.3: Methane monooxygenase (particulate)

Reaction catalysed:
Methane + quinol + O(2) = methanol + quinone + H(2)O
Systematic name:
Methane,quinol:oxygen oxidoreductase

EC 1.14.13.25: Methane monooxygenase (soluble)

Reaction catalysed:
Methane + NAD(P)H + O(2) = methanol + NAD(P)(+) + H(2)O
Systematic name:
Methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)
Alternative Name(s):
  • Methane hydroxylase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF04896
Domain description: Ammonia monooxygenase/methane monooxygenase, subunit C
Occurring in:
  1. Ammonia monooxygenase/methane monooxygenase, subunit C family protein
The deposited structure of PDB entry 7s4j contains 3 copies of Pfam domain PF04896 (Ammonia monooxygenase/methane monooxygenase, subunit C) in Ammonia monooxygenase/methane monooxygenase, subunit C family protein. Showing 1 copy in chain B [auth C].

PF02461
Domain description: Ammonia monooxygenase
Occurring in:
  1. Particulate methane monooxygenase beta subunit
The deposited structure of PDB entry 7s4j contains 3 copies of Pfam domain PF02461 (Ammonia monooxygenase) in Particulate methane monooxygenase beta subunit. Showing 1 copy in chain C [auth B].

PF04744
Domain description: Monooxygenase subunit B protein
Occurring in:
  1. Particulate methane monooxygenase alpha subunit
The deposited structure of PDB entry 7s4j contains 3 copies of Pfam domain PF04744 (Monooxygenase subunit B protein) in Particulate methane monooxygenase alpha subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003393
Domain description: Ammonia monooxygenase/particulate methane monooxygenase, subunit A
Occurring in:
  1. Particulate methane monooxygenase beta subunit
IPR006980
Domain description: Ammonia monooxygenase/particulate methane monooxygenase, subunit C
Occurring in:
  1. Ammonia monooxygenase/methane monooxygenase, subunit C family protein
IPR006833
Domain description: Ammonia monooxygenase/particulate methane monooxygenase, subunit B
Occurring in:
  1. Particulate methane monooxygenase alpha subunit
IPR023349
Domain description: Ammonia monooxygenase/particulate methane monooxygenase, subunit C domain superfamily
Occurring in:
  1. Ammonia monooxygenase/methane monooxygenase, subunit C family protein
IPR037001
Domain description: Ammonia/particulate methane monooxygenase, subunit A superfamily
Occurring in:
  1. Particulate methane monooxygenase beta subunit
IPR023303
Domain description: Ammonia/methane monooxygenase, subunit B, C-terminal
Occurring in:
  1. Particulate methane monooxygenase alpha subunit
IPR023141
Domain description: Ammonia/methane monooxygenase, subunit B, hairpin domain superfamily
Occurring in:
  1. Particulate methane monooxygenase alpha subunit
IPR023301
Domain description: Ammonia/methane monooxygenase, subunitB, N-terminal
Occurring in:
  1. Particulate methane monooxygenase alpha subunit

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