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Structure of a cell-entry defective human adenovirus provides insights into precursor proteins and capsid maturation

Electron Microscopy
3.72Å resolution
PDB entry 7s78 coloured by chain, front view.
PDB entry 7s78 coloured by chain, side view.
PDB entry 7s78 coloured by chain, top view.
Source organism: Human adenovirus 5
Assembly composition:
hetero 1860-mer (preferred)
Entry contents: 8 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 1860-mer
PDBe Complex ID: PDB-CPX-136685

Macromolecules

Hexon protein
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 952 amino acids
Theoretical weight: 108.11 KDa
Source organism: Human adenovirus 5
Hexon protein in PDB entry 7s78, assembly 1, front view.
Hexon protein in PDB entry 7s78, assembly 1, side view.
Hexon protein in PDB entry 7s78, assembly 1, top view.
1952100200300400500600700800900
 
500
UniProt
P04133
Chains
Domains
Flexibility predictions
Sequence conservation
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Penton protein
Chain: N
Length: 571 amino acids
Theoretical weight: 63.36 KDa
Source organism: Human adenovirus 5
Penton protein in PDB entry 7s78, assembly 1, front view.
Penton protein in PDB entry 7s78, assembly 1, side view.
Penton protein in PDB entry 7s78, assembly 1, top view.
157150100150200250300350400450500550
 
200400MRRAAMYEEGPPPSYESVVSAAPVAAALGSPFDAPLDPPFVPPRYLRPTGGRNSIRYSELAPLFDTTRVYLVDNKSTDVASLNYQNDHSNFLTTVIQNNDYSPGEASTQTINLDDRSHWGGDLKTILHTNMPNVNEFMFTNKFKARVMVSRLPTKDNQVELKYEWVEFTLPEGNYSETMTIDLMNNAIVEHYLKVGRQNGVLESDIGVKFDTRNFRLGFDPVTGLVMPGVYTNEAFHPDIILLPGCGVDFTHSRLSNLLGIRKRQPFQEGFRITYDDLEGGNIPALLDVDAYQASLKDDTEQGGGGAGGSNSSGSGAEENSNAAAAAMQPVEDMNDHAIRGDTFATRAEEKRAEAEAAAEAAAPAAQPEVEKPQKKPVIKPLTEDSKKRSYNLISNDSTFTQYRSWYLAYNYGDPQTGIRSWTLLCTPDVTCGSEQVYWSLPDMMQDPVTFRSTRQISNFPVVGAELLPVHSKSFYNDQAVYSQLIRQFTSLTHVFNRFPENQILARPPAPTITTVSENVPALTDHGTLPLRNSIGGVQRVTITDARRRTCPYVYKALGIVSPRVLSSRTF
UniProt
P12538
Chains
Domains
Flexibility predictions
Sequence conservation
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Pre-hexon-linking protein IIIa
Chain: M
Length: 585 amino acids
Theoretical weight: 65.32 KDa
Source organism: Human adenovirus 5
Pre-hexon-linking protein IIIa in PDB entry 7s78, assembly 1, front view.
Pre-hexon-linking protein IIIa in PDB entry 7s78, assembly 1, side view.
Pre-hexon-linking protein IIIa in PDB entry 7s78, assembly 1, top view.
158550100150200250300350400450500550
 
200400MMQDATDPAVRAALQSQPSGLNSTDDWRQVMDRIMSLTARNPDAFRQQPQANRLSAILEAVVPARANPTHEKVLAIVNALAENRAIRPDEAGLVYDALLQRVARYNSGNVQTNLDRLVGDVREAVAQRERAQQQGNLGSMVALNAFLSTQPANVPRGQEDYTNFVSALRLMVTETPQSEVYQSGPDYFFQTSRQGLQTVNLSQAFKNLQGLWGVRAPTGDRATVSSLLTPNSRLLLLLIAPFTDSGSVSRDTYLGHLLTLYREAIGQAHVDEHTFQEITSVSRALGQEDTGSLEATLNYLLTNRRQKIPSLHSLNSEEERILRYVQQSVSLNLMRDGVTPSVALDMTARNMEPGMYASNRPFINRLMDYLHRAAAVNPEYFTNAILNPHWLPPPGFYTGGFEVPEGNDGFLWDDIDDSVFSPQPQTLLELQQREQAEAALRKESFRRPSSLSDLGAAAPRSDASSPFPSLIGSLTSTRTTRPRLLGEEEYLNNSLLQPQREKNLPPAFPNNGIESLVDKMSRWKTYAQEHRDVPGPRPPTRRQRHDRQRGLVWEDDDSADDSSVLDLGGSGNPFAHLRPRLGRMF
UniProt
P12537
Chains
Domains
Flexibility predictions
Sequence conservation
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Hexon-interlacing protein
Chains: P, Q, R, S
Length: 140 amino acids
Theoretical weight: 14.47 KDa
Source organism: Human adenovirus 5
Hexon-interlacing protein in PDB entry 7s78, assembly 1, front view.
Hexon-interlacing protein in PDB entry 7s78, assembly 1, side view.
Hexon-interlacing protein in PDB entry 7s78, assembly 1, top view.
1140102030405060708090100110120130140
 
50100MSTNSFDGSIVSSYLTTRMPPWAGVRQNVMGSSIDGRPVLPANSTTLTYETVSGTPLETAASAAASAAAATARGIVTDFAFLSPLASSAASRSSARDDKLTALLAQLDSLTRELNVVSQQLLDLRQQVSALKASSPPNAV
UniProt
P03281
Chains
Domains
Sequence conservation
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Pre-hexon-linking protein VIII
Chains: U, V
Length: 227 amino acids
Theoretical weight: 24.71 KDa
Source organism: Human adenovirus 5
Pre-hexon-linking protein VIII in PDB entry 7s78, assembly 1, front view.
Pre-hexon-linking protein VIII in PDB entry 7s78, assembly 1, side view.
Pre-hexon-linking protein VIII in PDB entry 7s78, assembly 1, top view.
122720406080100120140160180200220
 
100200MSKEIPTPYMWSYQPQMGLAAGAAQDYSTRINYMSAGPHMISRVNGIRAHRNRILLEQAAITTTPRNNLNPRSWPAALVYQESPAPTTVVLPRDAQAEVQMTNSGAQLAGGFRHRVRSPGQGITHLTIRGRGIQLNDESVSSSLGLRPDGTFQIGGAGRPSFTPRQAILTLQTSSSEPRSGGIGTLQFIEEFVPSVYFNPFSGPPGHYPDQFIPNFDAVKDSADGYD
UniProt
P24936
PRO_0000036495
PRO_0000036496
Chains
Domains
Sequence conservation
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Pre-protein VI
Chains: 0, 1, 2, 3, 4, W, X, Y, Z
Length: 250 amino acids
Theoretical weight: 27.03 KDa
Source organism: Human adenovirus 5
Pre-protein VI in PDB entry 7s78, assembly 1, front view.
Pre-protein VI in PDB entry 7s78, assembly 1, side view.
Pre-protein VI in PDB entry 7s78, assembly 1, top view.
125020406080100120140160180200220240
 
100200
UniProt
P24937
PRO_0000036547
PRO_0000036548
PRO_0000439553
Chains
Domains
Flexibility predictions
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Unknown-1
Chain: 5
Length: 16 amino acids
Theoretical weight: 1.38 KDa
Source organism: Human adenovirus 5
Unknown-1 in PDB entry 7s78, assembly 1, front view.
Unknown-1 in PDB entry 7s78, assembly 1, side view.
Unknown-1 in PDB entry 7s78, assembly 1, top view.
116246810121416
 
51015****************
Chains
Chain DA (auth 5)
Sequence conservation
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Unknown-2
Chain: 6
Length: 10 amino acids
Theoretical weight: 869 Da
Source organism: Human adenovirus 5
Unknown-2 in PDB entry 7s78, assembly 1, front view.
Unknown-2 in PDB entry 7s78, assembly 1, side view.
Unknown-2 in PDB entry 7s78, assembly 1, top view.
11012345678910
 
510**********
Chains
Chain EA (auth 6)
Sequence conservation
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