› 7s8q

X-ray diffraction
2.08Å resolution

Crystal Structure of HLA A*1101 in complex with KTNGNAFIGK, an 10-mer epitope from Influenza B

Released:
DOI: 10.2210/pdb7s8q/pdb
PDB entry 7s8q coloured by chain, front view.
PDB entry 7s8q coloured by chain, side view.
PDB entry 7s8q coloured by chain, top view.
Source organisms:
Primary publication:
HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people.
Habel JR, Nguyen AT, Rowntree LC, Szeto C, Mifsud NA, Clemens EB, Loh L, Chen W, Rockman S, Nelson J, Davies J, Miller A, Tong SYC, Rossjohn J, Gras S, Purcell AW, Hensen L, Kedzierska K, Illing PT
OpenAccess logo PLoS Pathog 18 e1010337 (2022)
PMID: 35255101

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-138142 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 278 amino acids
Theoretical weight: 32.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: U5YJK1 (Residues: 25-302; Coverage: 89%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Nucleoprotein Chains: C, F
Molecule details ›
Chains: C, F
Length: 10 amino acids
Theoretical weight: 1.05 KDa
Source organism: Influenza B virus
Expression system: Not provided
UniProt:
  • Canonical: P04666 (Residues: 511-520; Coverage: 2%)
Gene name: NP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43
Unit cell:
a: 119.481Å b: 119.481Å c: 63.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.217
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

4 review citations

T Cell Epitope Discovery in the Context of Distinct and Unique Indigenous HLA Profiles.
Hensen et al. (2022)
3 more

3 mentions without citation

HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people.
Habel et al. (2022)
2 more