› 7sa9

X-ray diffraction
1.69Å resolution

Human MUC16 SEA5 Domain

Released:
DOI: 10.2210/pdb7sa9/pdb
PDB entry 7sa9 coloured by chain, front view.
PDB entry 7sa9 coloured by chain, side view.
PDB entry 7sa9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a human MUC16 SEA domain reveals insight into the nature of the CA125 tumor marker.
White B, Patterson M, Karnwal S, Brooks CL
Proteins 90 1210-1218 (2022)
PMID: 35037700

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucin-16 Chains: A, B
Molecule details ›
Chains: A, B
Length: 196 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WXI7 (Residues: 12665-12857; Coverage: 1%)
Gene names: CA125, MUC16
Sequence domains: SEA domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2
Unit cell:
a: 78.54Å b: 90.145Å c: 42.821Å
α: 90° β: 102.877° γ: 90°
R-values:
R R work R free
0.201 0.2 0.216
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

The Potential Role of MUC16 (CA125) Biomarker in Lung Cancer: A Magic Biomarker but with Adversity.
Saad et al. (2022)
1 more

1 mention without citation

Crystal structure of a human MUC16 SEA domain reveals insight into the nature of the CA125 tumor marker.
White et al. (2022)