› 7saq

Electron Microscopy
2.9Å resolution

Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1

Released:
DOI: 10.2210/pdb7saq/pdb
PDB entry 7saq coloured by chain, front view.
PDB entry 7saq coloured by chain, side view.
PDB entry 7saq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, Dickson DW, Fu JY, Ogorzalek Loo RR, Loo JA, Eisenberg DS
Nature 605 304-309 (2022)
PMID: 35344984
Related structures: EMD-24953

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein 106B Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 274 amino acids
Theoretical weight: 31.16 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NUM4 (Residues: 1-274; Coverage: 100%)
Gene name: TMEM106B
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 20 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-24953

Quick links

Citations

6 review citations

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Scheres et al. (2023)
5 more

1 mention without citation

Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Jiang et al. (2022)