› 7se9

X-ray diffraction
1.75Å resolution

Crystal structure of human Fibrillarin in complex with compound 1 from single soak

Released:
DOI: 10.2210/pdb7se9/pdb
PDB entry 7se9 coloured by chain, front view.
PDB entry 7se9 coloured by chain, side view.
PDB entry 7se9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.
Shi Y, El-Deeb IM, Masic V, Hartley-Tassell L, Maggioni A, Itzstein MV, Ve T
OpenAccess logo Pharmaceuticals (Basel) 15 (2021)
PMID: 35056083

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
rRNA 2'-O-methyltransferase fibrillarin Chains: A, B
Molecule details ›
Chains: A, B
Length: 242 amino acids
Theoretical weight: 26.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22087 (Residues: 83-321; Coverage: 75%)
Gene names: FBL, FIB1, FLRN
Sequence domains: Fibrillarin

Ligands and Environments

3 bound ligands:
Ligand 8W1 2 x 8W1
Ligand FMT 8 x FMT
Ligand DMS 2 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21212
Unit cell:
a: 67.605Å b: 138.548Å c: 68.967Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.222
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.
Shi et al. (2021)