› 7sed

X-ray diffraction
1.9Å resolution

Crystal structure of human Fibrillarin in complex with compound 2a

Released:
DOI: 10.2210/pdb7sed/pdb
PDB entry 7sed coloured by chain, front view.
PDB entry 7sed coloured by chain, side view.
PDB entry 7sed coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.
Shi Y, El-Deeb IM, Masic V, Hartley-Tassell L, Maggioni A, Itzstein MV, Ve T
OpenAccess logo Pharmaceuticals (Basel) 15 (2021)
PMID: 35056083

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
rRNA 2'-O-methyltransferase fibrillarin Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 26.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22087 (Residues: 83-321; Coverage: 75%)
Gene names: FBL, FIB1, FLRN
Sequence domains: Fibrillarin

Ligands and Environments

2 bound ligands:
Ligand 8VD 1 x 8VD
Ligand FMT 1 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2221
Unit cell:
a: 69.291Å b: 139.581Å c: 66.249Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.225
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.
Shi et al. (2021)