Function and Biology

EC 2.1.1.44: L-histidine N(alpha)-methyltransferase

Reaction catalysed:
(1a) S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N(alpha)-methyl-L-histidine
Systematic name:
S-adenosyl-L-methionine:L-histidine N(alpha)-methyltransferase (hercynine-forming)
Alternative Name(s):
  • Dimethylhistidine N-methyltransferase
  • Dimethylhistidine methyltransferase
  • Histidine-alpha-N-methyltransferase
  • S-adenosyl-L-methionine:N(alpha),N(alpha)-dimethyl-L-histidine N(alpha)-methyltransferase
  • S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase

Sequence family

Pfam Protein family (Pfam)
PF10017
Domain description: Histidine-specific methyltransferase, SAM-dependent
Occurring in:
  1. Histidine N-alpha-methyltransferase
The deposited structure of PDB entry 7sex contains 1 copy of Pfam domain PF10017 (Histidine-specific methyltransferase, SAM-dependent) in Histidine N-alpha-methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Histidine N-alpha-methyltransferase
IPR035094
Domain description: Histidine N-alpha-methyltransferase
Occurring in:
  1. Histidine N-alpha-methyltransferase
IPR019257
Domain description: Histidine-specific methyltransferase, SAM-dependent
Occurring in:
  1. Histidine N-alpha-methyltransferase
IPR032888
Domain description: Histidine N-alpha-methyltransferase, Actinobacteria-type
Occurring in:
  1. Histidine N-alpha-methyltransferase
IPR017804
Domain description: Methyltransferase EgtD-like
Occurring in:
  1. Histidine N-alpha-methyltransferase