7sgl

Electron Microscopy
3Å resolution

DNA-PK complex of DNA end processing

Released:
Source organism: Homo sapiens
Related structures: EMD-25113

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-122004 (preferred)
Entry contents:
4 distinct polypeptide molecules
1 distinct DNA molecule
Macromolecules (5 distinct):
DNA-dependent protein kinase catalytic subunit Chain: A
Molecule details ›
Chain: A
Length: 4128 amino acids
Theoretical weight: 469.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P78527 (Residues: 1-4128; Coverage: 100%)
Gene names: HYRC, HYRC1, PRKDC
Sequence domains:
X-ray repair cross-complementing protein 6 Chain: B
Molecule details ›
Chain: B
Length: 612 amino acids
Theoretical weight: 70.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P12956 (Residues: 1-609; Coverage: 100%)
Gene names: G22P1, XRCC6
Sequence domains:
X-ray repair cross-complementing protein 5 Chain: C
Molecule details ›
Chain: C
Length: 732 amino acids
Theoretical weight: 82.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13010 (Residues: 1-732; Coverage: 100%)
Gene names: G22P2, XRCC5
Sequence domains:
Protein artemis Chain: D
Molecule details ›
Chain: D
Length: 701 amino acids
Theoretical weight: 79.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96SD1 (Residues: 1-692; Coverage: 100%)
Gene names: ARTEMIS, ASCID, DCLRE1C, SCIDA, SNM1C
Sequence domains: DNA repair metallo-beta-lactamase
Hairpin_1 Chains: E, F
Molecule details ›
Chains: E, F
Length: 54 nucleotides
Theoretical weight: 16.64 KDa

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-25113
Expression system: Homo sapiens