› 7si0

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275994 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Immunoglobulin heavy constant epsilon Chains: A, B, G, H
Molecule details ›
Chains: A, B, G, H
Length: 247 amino acids
Theoretical weight: 27.55 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
813 Variable fragment Heavy chain Chains: C, E, I, K
Molecule details ›
Chains: C, E, I, K
Length: 123 amino acids
Theoretical weight: 13.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
813 Variable fragment Light chain Chains: D, F, J, L
Molecule details ›
Chains: D, F, J, L
Length: 134 amino acids
Theoretical weight: 14.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN
Carbohydrate polymer
1 bound ligand:
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-1
Spacegroup: P212121
Unit cell:
a: 98.958Å b: 132.005Å c: 177.434Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.21 0.261
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Accelerating therapeutic protein design with computational approaches toward the clinical stage.
Chen et al. (2023)
1 more