› 7si5

X-ray diffraction
1.75Å resolution

CRYSTAL STRUCTURE OF EED WITH MRTX-1919

Released:
DOI: 10.2210/pdb7si5/pdb
PDB entry 7si5 coloured by chain, front view.
PDB entry 7si5 coloured by chain, side view.
PDB entry 7si5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gunn RJ, Burns AC, Lawson JD, Marx MA

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-522069 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycomb protein EED Chain: A
Molecule details ›
Chain: A
Length: 402 amino acids
Theoretical weight: 46.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75530 (Residues: 40-441; Coverage: 91%)
Gene name: EED
Sequence domains: WD domain, G-beta repeat

Ligands and Environments

4 bound ligands:
Ligand NA 2 x NA
Ligand 9L0 1 x 9L0
Ligand EDO 2 x EDO
Ligand FMT 13 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 57.86Å b: 85.03Å c: 91.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.151 0.187
Expression system: Escherichia coli

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