› 7sin

Electron Microscopy
5.9Å resolution

Structure of negative allosteric modulator-bound inactive human calcium-sensing receptor

Released:
DOI: 10.2210/pdb7sin/pdb
PDB entry 7sin coloured by chain, front view.
PDB entry 7sin coloured by chain, side view.
PDB entry 7sin coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Symmetric activation and modulation of the human calcium-sensing receptor.
Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR
Proc Natl Acad Sci U S A 118 (2021)
PMID: 34916296
Related structures: EMD-25145

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Extracellular calcium-sensing receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 878 amino acids
Theoretical weight: 99.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P41180 (Residues: 1-870; Coverage: 80%)
Gene names: CASR, GPRC2A, PCAR1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand YP1 2 x YP1
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.9Å
Relevant EMDB volumes: EMD-25145
Expression system: Homo sapiens

Quick links

Citations

2 review citations

G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery.
Zhang et al. (2024)
1 more

4 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
3 more