› 7sj1

Electron Microscopy
2.9Å resolution

Structure of shaker-W434F

Released:
DOI: 10.2210/pdb7sj1/pdb
PDB entry 7sj1 coloured by chain, front view.
PDB entry 7sj1 coloured by chain, side view.
PDB entry 7sj1 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure of the Shaker Kv channel and mechanism of slow C-type inactivation.
Tan XF, Bae C, Stix R, Fernández-Mariño AI, Huffer K, Chang TH, Jiang J, Faraldo-Gómez JD, Swartz KJ
Sci Adv 8 eabm7814 (2022)
PMID: 35302848
Related structures: EMD-25152

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140153 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel protein Shaker Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 617 amino acids
Theoretical weight: 69.44 KDa
Source organism: Drosophila melanogaster
Expression system: Homo sapiens
UniProt:
  • Canonical: P08510 (Residues: 47-512, 513-655; Coverage: 93%)
Gene names: CG12348, Sh, mns
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand POV 32 x POV
Ligand K 2 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-25152
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Ionic channels in nerve membranes, 50 years on.
Hille B. (2022)
1 more

7 mentions without citation

Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads.
Chandy et al. (2023)
6 more