7sj3

X-ray diffraction
2.51Å resolution

Structure of CDK4-Cyclin D3 bound to abemaciclib

Released:
Model geometry
Fit model/data
Source organism: Homo sapiens
Entry authors: Hilgers MT, Pelletier LA

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145932 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent kinase 4 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 34.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11802 (Residues: 2-303; Coverage: 100%)
Gene name: CDK4
Sequence domains: Protein kinase domain
G1/S-specific cyclin-D3 Chain: B
Molecule details ›
Chain: B
Length: 259 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30281 (Residues: 1-259; Coverage: 89%)
Gene name: CCND3
Sequence domains:

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P6522
Unit cell:
a: 117.654Å b: 117.654Å c: 170.278Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.2 0.234
Expression system: Spodoptera frugiperda