› 7sjl

Solution NMR

Solution NMR Structure of Immunoglobulin-like Domain of Human Neuregulin-1

Released:
DOI: 10.2210/pdb7sjl/pdb
PDB entry 7sjl coloured by chain, ensemble of 20 models, front view.
PDB entry 7sjl coloured by chain, ensemble of 20 models, side view.
PDB entry 7sjl coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Validated determination of NRG1 Ig-like domain structure by mass spectrometry coupled with computational modeling
Khaje NA, Eletsky A, Biehn SE, Mobley CK, Rogals MJ, Kim Y, Mishra SK, Doerksen RJ, Lindert S, Prestegard JH, Sharp JS
Commun Biol 5 452- (2022)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169705 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuregulin-1 Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q02297 (Residues: 34-133; Coverage: 16%)
Gene names: GGF, HGL, HRGA, NDF, NRG1, SMDF
Sequence domains: Immunoglobulin I-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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