› 7sk0

Electron Microscopy
3.33Å resolution

TWIK1 in MSP1D1 lipid nanodisc at pH 7.4

Released:
DOI: 10.2210/pdb7sk0/pdb
PDB entry 7sk0 coloured by chain, front view.
PDB entry 7sk0 coloured by chain, side view.
PDB entry 7sk0 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter.
Turney TS, Li V, Brohawn SG
OpenAccess logo Nat Commun 13 3232 (2022)
PMID: 35680900
Related structures: EMD-25168

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195561 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel subfamily K member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 336 amino acids
Theoretical weight: 38.27 KDa
Source organism: Rattus norvegicus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9Z2T2 (Residues: 1-336; Coverage: 100%)
Gene name: Kcnk1
Sequence domains: Ion channel

Ligands and Environments

2 bound ligands:
Ligand OCT 2 x OCT
Ligand K 5 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.33Å
Relevant EMDB volumes: EMD-25168
Expression system: Komagataella pastoris

Quick links

Citations

2 citation in other articles

Asymmetric gating of a human hetero-pentameric glycine receptor.
Liu et al. (2023)
1 more

1 mention without citation

Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter.
Turney et al. (2022)