› › Function and Biology

Cryo-EM structure of ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ, an intracellular Fab, and an extracellular Fab

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Cellular component: external side of plasma membrane

Quick links

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00048
Domain description: Small cytokines (intecrine/chemokine), interleukin-8 like
Occurring in:
  1. Stromal cell-derived factor 1
The deposited structure of PDB entry 7sk4 contains 1 copy of Pfam domain PF00048 (Small cytokines (intecrine/chemokine), interleukin-8 like) in Stromal cell-derived factor 1. Showing 1 copy in chain B.

PF00001
Domain description: 7 transmembrane receptor (rhodopsin family)
Occurring in:
  1. Atypical chemokine receptor 3
The deposited structure of PDB entry 7sk4 contains 1 copy of Pfam domain PF00001 (7 transmembrane receptor (rhodopsin family)) in Atypical chemokine receptor 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000276
Domain description: G protein-coupled receptor, rhodopsin-like
Occurring in:
  1. Atypical chemokine receptor 3
IPR001416
Domain description: Atypical chemokine receptor 3
Occurring in:
  1. Atypical chemokine receptor 3
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. CID25 Fab light chain
  2. CID25 Fab heavy chain
  3. CID24 Fab light chain
  4. CID24 Fab heavy chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. CID25 Fab light chain
  2. CID25 Fab heavy chain
  3. CID24 Fab light chain
  4. CID24 Fab heavy chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. CID25 Fab light chain
  2. CID25 Fab heavy chain
  3. CID24 Fab light chain
  4. CID24 Fab heavy chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. CID25 Fab light chain
  2. CID25 Fab heavy chain
  3. CID24 Fab light chain
  4. CID24 Fab heavy chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. CID25 Fab light chain
  2. CID25 Fab heavy chain
  3. CID24 Fab light chain
  4. CID24 Fab heavy chain
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. CID25 Fab light chain
  2. CID25 Fab heavy chain
  3. CID24 Fab light chain
  4. CID24 Fab heavy chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. CID25 Fab light chain
  2. CID25 Fab heavy chain
  3. CID24 Fab light chain
  4. CID24 Fab heavy chain
IPR001811
Domain description: Chemokine interleukin-8-like domain
Occurring in:
  1. Stromal cell-derived factor 1
IPR033899
Domain description: CXC Chemokine domain
Occurring in:
  1. Stromal cell-derived factor 1
IPR036048
Domain description: Chemokine interleukin-8-like superfamily
Occurring in:
  1. Stromal cell-derived factor 1
IPR017452
Domain description: GPCR, rhodopsin-like, 7TM
Occurring in:
  1. Atypical chemokine receptor 3
IPR047143
Domain description: G-protein coupled estrogen receptor 1-like
Occurring in:
  1. Atypical chemokine receptor 3

Quick links