› 7sl8

Electron Microscopy
3.4Å resolution

CryoEM structure of SGLT1 at 3.4 A resolution

Released:
DOI: 10.2210/pdb7sl8/pdb
PDB entry 7sl8 coloured by chain, front view.
PDB entry 7sl8 coloured by chain, side view.
PDB entry 7sl8 coloured by chain, top view.
Source organisms:
Primary publication:
Structure and mechanism of the SGLT family of glucose transporters.
Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L
Nature 601 274-279 (2022)
PMID: 34880492
Related structures: EMD-25194

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210578 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sodium/glucose cotransporter 1 Chain: A
Molecule details ›
Chain: A
Length: 673 amino acids
Theoretical weight: 74.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13866 (Residues: 1-664; Coverage: 100%)
Gene names: NAGT, SGLT1, SLC5A1
Sequence domains: Sodium:solute symporter family
nanobody Nb1 Chain: B
Molecule details ›
Chain: B
Length: 126 amino acids
Theoretical weight: 14.13 KDa
Source organism: synthetic construct
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

1 bound ligand:
Ligand CLR 1 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-25194
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Recent advances on the inhibition of human solute carriers: Therapeutic implications and mechanistic insights.
Wright et al. (2022)
4 more

3 mentions without citation

Structure and mechanism of the SGLT family of glucose transporters.
Han et al. (2022)
2 more