› 7smm

Electron Microscopy
2.5Å resolution

Cryo-EM structure of Torpedo acetylcholine receptor in apo form

Released:
DOI: 10.2210/pdb7smm/pdb
PDB entry 7smm coloured by chain, front view.
PDB entry 7smm coloured by chain, side view.
PDB entry 7smm coloured by chain, top view.
Source organism: Tetronarce californica
Primary publication:
Structural mechanism of muscle nicotinic receptor desensitization and block by curare.
Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE
Nat Struct Mol Biol 29 386-394 (2022)
PMID: 35301478
Related structures: EMD-25202

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136090 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (8 distinct):
Acetylcholine receptor subunit alpha Chains: A, D
Molecule details ›
Chains: A, D
Length: 437 amino acids
Theoretical weight: 50.17 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P02710 (Residues: 25-461; Coverage: 100%)
Gene name: CHRNA1
Sequence domains:
Acetylcholine receptor subunit delta Chain: B
Molecule details ›
Chain: B
Length: 501 amino acids
Theoretical weight: 57.63 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P02718 (Residues: 22-522; Coverage: 100%)
Gene name: chrnd
Sequence domains:
Acetylcholine receptor subunit beta Chain: C
Molecule details ›
Chain: C
Length: 469 amino acids
Theoretical weight: 53.73 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P02712 (Residues: 25-493; Coverage: 100%)
Gene name: CHRNB1
Sequence domains:
Acetylcholine receptor subunit gamma Chain: E
Molecule details ›
Chain: E
Length: 489 amino acids
Theoretical weight: 56.34 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P02714 (Residues: 18-506; Coverage: 100%)
Gene name: CHRNG
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
4 bound ligands:
Ligand POV 8 x POV
Ligand CLR 3 x CLR
Ligand NAG 3 x NAG
Ligand DD9 1 x DD9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-25202

Quick links

Citations

6 review citations

Clinical and Pathologic Features of Congenital Myasthenic Syndromes Caused by 35 Genes-A Comprehensive Review.
Ohno et al. (2023)
5 more

5 mentions without citation

Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids.
Barrantes FJ. (2023)
4 more