› 7soq

X-ray diffraction
1.15Å resolution

LaM domain of human LARP1 in complex with AAA RNA

Released:
DOI: 10.2210/pdb7soq/pdb
Model geometry
Fit model/data
PDB entry 7soq coloured by chain, front view.
PDB entry 7soq coloured by chain, side view.
PDB entry 7soq coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of 3'-end poly(A) RNA recognition by LARP1.
Kozlov G, Mattijssen S, Jiang J, Nyandwi S, Sprules T, Iben JR, Coon SL, Gaidamakov S, Noronha AM, Wilds CJ, Maraia RJ, Gehring K
OpenAccess logo Nucleic Acids Res (2022)
PMID: 35979957

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-250826 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
La-related protein 1 Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 11.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6PKG0 (Residues: 400-487; Coverage: 8%)
Gene names: KIAA0731, LARP, LARP1
Sequence domains: La domain
RNA (5'-R(*AP*AP*A)-3') Chain: B
Molecule details ›
Chain: B
Length: 3 nucleotides
Theoretical weight: 943 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 36.915Å b: 46.474Å c: 59.135Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.176 0.188
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 citations in other articles

A unique poly(A) tail profile uncovers the stability and translational activation of TOP transcripts during neuronal differentiation.
Baptissart et al. (2023)

1 mention without citation

Structural basis of 3'-end poly(A) RNA recognition by LARP1.
Kozlov et al. (2022)