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Chlorella virus Hyaluronan Synthase bound to UDP-GlcNAc

Electron Microscopy
2.7Å resolution
PDB entry 7sp8 coloured by chain, front view.
PDB entry 7sp8 coloured by chain, side view.
PDB entry 7sp8 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hyaluronan synthase and IG-heavy chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 34153.93 Å2
Buried surface area: 5333.92 Å2
Dissociation area: 783.11 Å2
Dissociation energy (ΔGdiss): -6.82 kcal/mol
Dissociation entropy (TΔSdiss): 12.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-207994

Macromolecules

Hyaluronan synthase
Chain: A
Length: 570 amino acids
Theoretical weight: 65.34 KDa
Source organism: Paramecium bursaria Chlorella virus CZ-2
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: M1H2Q1 (Residues: 2-561; Coverage: 100%)
Gene names: CZ-2_118R, PBCVCZ2_118R
Pfam: Glycosyltransferase like family 2
InterPro: Nucleotide-diphospho-sugar transferases
Hyaluronan synthase in PDB entry 7sp8, assembly 1, front view.
Hyaluronan synthase in PDB entry 7sp8, assembly 1, side view.
Hyaluronan synthase in PDB entry 7sp8, assembly 1, top view.
PDBe-KB: UniProt Coverage View: M1H2Q1  
157050100150200250300350400450500550
 
200400MGTSWRTIVSANLFAVGGALLMLAPAIVGYVFQWNIGVSAVWGISVYGVFVLGFYIAQIVFSEFNRMRLSDWISLRPDNWNATRVAVIIAGYREDPFMFKKCLESVRDSEYGNVARLICVIDGDEEEDLKMAEIYKQVYNDNVKKPGVVLCESENKNGSTIDSDVSKNICILQPHRGKRESLYTGFQLASMDPSVHAVVLIDSDTVLEKNAILEVVYPLSCDPNIKAVAGECKIWNTDTILSMLVSWRYFSAFNVERGAQSLWKTVQCVGGPLGAYTIDIINEIKDPWITQTFLGNKCTYGDNRRLTNEVLMRGKKIVYTPFAVGWSDSPTNVMRYIVQQTRWSKSWCREIWYTLGSAWKHGFSGIYLAFECMYQIMYFFLVMYLFSYIAIKADIRAQTATVLVSTLVTIIKSSYLALRAKNLKAFYFVLYTYVYFFCMIPARITAMFTMFDIAWGTRGGNAKMTIGARVWLWAKQFLITYMWWAGVLAAGVYSIVDNWYFDWADIQYRFALVGICSYLVFVSIVLVIYLIGKITTWNYTPLQKELIEERYLHNASENAPEVLEHHHHHH
UniProt
M1H2Q1
Chains
Domains
Secondary structure
Ligand binding sites
Sequence conservation
Molecule details ›

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Nanobody 872
Chain: B
Length: 134 amino acids
Theoretical weight: 14.78 KDa
Source organism: Lama glama
Expression system: Escherichia coli K-12
InterPro:
Nanobody 872 in PDB entry 7sp8, assembly 1, front view.
Nanobody 872 in PDB entry 7sp8, assembly 1, side view.
Nanobody 872 in PDB entry 7sp8, assembly 1, top view.
1134102030405060708090100110120130
 
50100QVQLVESGGGLVQAGGSLKVSCAASGRAFKTYRMAWFRQAPGKEREFVSGISALETTYYADSVKGRFTISRDNTKNTVSLQMDSLKPEDTAVYYCAARRYGGTDYTTTGSYDYWGQGTQVTVSSHHHHHHEPEA
Chains
Chain B (auth B)
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
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Nanobody 881
Chain: C
Length: 137 amino acids
Theoretical weight: 15.27 KDa
Source organism: Lama glama
Expression system: Escherichia coli K-12
InterPro:
Nanobody 881 in PDB entry 7sp8, assembly 1, front view.
Nanobody 881 in PDB entry 7sp8, assembly 1, side view.
Nanobody 881 in PDB entry 7sp8, assembly 1, top view.
1137102030405060708090100110120130
 
50100QVQLVESGGGLVQAGGSLRLACAASGRIFSSDTLAWFRRAPGKEREFVAASRWSGGGTDYADSVKGRFTFSRDNTRNTMCLEMNSLKPEDTAVYYCALRTARDSYYYTRNPTGYDYWGQGTQVTVSSHHHHHHEPEA
Chains
Chain C (auth C)
Domains
Secondary structure
Interaction interfaces
Sequence conservation
Molecule details ›

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