› 7spt

X-ray diffraction
2.1Å resolution

Crystal structure of exofacial state human glucose transporter GLUT3

Released:
DOI: 10.2210/pdb7spt/pdb
PDB entry 7spt coloured by chain, front view.
PDB entry 7spt coloured by chain, side view.
PDB entry 7spt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.
Wang N, Zhang S, Yuan Y, Xu H, Defossa E, Matter H, Besenius M, Derdau V, Dreyer M, Halland N, He KH, Petry S, Podeschwa M, Tennagels N, Jiang X, Yan N
OpenAccess logo Nat Commun 13 2632 (2022)
PMID: 35552392

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 2, facilitated glucose transporter member 3 Chain: A
Molecule details ›
Chain: A
Length: 523 amino acids
Theoretical weight: 57.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11169 (Residues: 1-496; Coverage: 100%)
Gene names: GLUT3, SLC2A3
Sequence domains: Sugar (and other) transporter

Ligands and Environments

2 bound ligands:
Ligand OLC 3 x OLC
Ligand GLC 1 x GLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: P21
Unit cell:
a: 48.231Å b: 118.43Å c: 53.728Å
α: 90° β: 103.16° γ: 90°
R-values:
R R work R free
0.179 0.177 0.22
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT inhibitors.
Temre et al. (2022)
5 other articles