› 7sr3

X-ray diffraction
2.49Å resolution

Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDL

Released:
DOI: 10.2210/pdb7sr3/pdb
PDB entry 7sr3 coloured by chain, front view.
PDB entry 7sr3 coloured by chain, side view.
PDB entry 7sr3 coloured by chain, top view.
Source organisms:
Primary publication:
Effects of HLA single chain trimer design on peptide presentation and stability.
Finton KAK, Rupert PB, Friend DJ, Dinca A, Lovelace ES, Buerger M, Rusnac DV, Foote-McNabb U, Chour W, Heath JR, Campbell JS, Pierce RH, Strong RK
OpenAccess logo Front Immunol 14 1170462 (2023)
PMID: 37207206

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-279062 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Beta-2-microglobulin; Ig-like domain-containing protein; Protein E7 Chains: A, C
Molecule details ›
Chains: A, C
Length: 427 amino acids
Theoretical weight: 48 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P03129 (Residues: 11-22; Coverage: 12%)
  • Canonical: P16213 (Residues: 21-119; Coverage: 100%)
  • Canonical: A0A6S7XV52 (Residues: 25-299; Coverage: 81%)
Gene names: B2M, E7, HLA-A
Sequence domains:
VHH Chains: B, D
Molecule details ›
Chains: B, D
Length: 116 amino acids
Theoretical weight: 12.54 KDa
Source organism: Lama glama
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P41212
Unit cell:
a: 118.093Å b: 118.093Å c: 262.205Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.225 0.248
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes.
Sharma et al. (2024)
1 more

1 mention without citation

Effects of HLA single chain trimer design on peptide presentation and stability.
Finton et al. (2023)