› 7ssp

Electron Microscopy
3.5Å resolution

Structure of the human COQ7:COQ9 complex by single-particle electron cryo-microscopy, unliganded state

Released:
DOI: 10.2210/pdb7ssp/pdb
PDB entry 7ssp coloured by chain, front view.
PDB entry 7ssp coloured by chain, side view.
PDB entry 7ssp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and functionality of a multimeric human COQ7:COQ9 complex.
Manicki M, Aydin H, Abriata LA, Overmyer KA, Guerra RM, Coon JJ, Dal Peraro M, Frost A, Pagliarini DJ
Mol Cell (2022)
PMID: 36306796
Related structures: EMD-25412

Function and Biology Details

Reaction catalysed: 
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol + a reduced acceptor + O(2) = 3-demethylubiquinol + acceptor + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130884 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ubiquinone biosynthesis protein COQ9, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 318 amino acids
Theoretical weight: 35.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75208 (Residues: 1-318; Coverage: 100%)
Gene names: C16orf49, COQ9, HSPC326, PSEC0129
Sequence domains:
5-demethoxyubiquinone hydroxylase, mitochondrial Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 217 amino acids
Theoretical weight: 24.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99807 (Residues: 1-217; Coverage: 100%)
Gene name: COQ7
Sequence domains: Ubiquinone biosynthesis protein COQ7

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-25412
Expression system: Escherichia coli

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Citations

3 review citations

Coenzyme Q biochemistry and biosynthesis.
Guerra et al. (2023)
2 more

4 mentions without citation

Structure and functionality of a multimeric human COQ7:COQ9 complex.
Manicki et al. (2022)
3 more