› 7ssx

Electron Microscopy
2.89Å resolution

Structure of human Kv1.3

Released:
DOI: 10.2210/pdb7ssx/pdb
PDB entry 7ssx coloured by chain, front view.
PDB entry 7ssx coloured by chain, side view.
PDB entry 7ssx coloured by chain, top view.
Source organisms:
Primary publication:
Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.
Selvakumar P, Fernández-Mariño AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR
OpenAccess logo Nat Commun 13 3854 (2022)
PMID: 35788586
Related structures: EMD-25416

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-238728 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Green fluorescent protein; Potassium voltage-gated channel subfamily A member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 856 amino acids
Theoretical weight: 95.02 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P22001 (Residues: 1-575; Coverage: 100%)
  • Canonical: P42212 (Residues: 2-238; Coverage: 100%)
Gene names: GFP, HGK5, KCNA3
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand K 3 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.89Å
Relevant EMDB volumes: EMD-25416
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Microglial ion channels: Key players in non-cell autonomous neurodegeneration.
Sarkar S. (2022)
1 more

2 mentions without citation

Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads.
Chandy et al. (2023)
1 more