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Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: regulation of T cell proliferation
Cellular component: membrane

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4
The deposited structure of PDB entry 7su0 contains 2 copies of Pfam domain PF07686 (Immunoglobulin V-set domain) in Cytotoxic T-lymphocyte protein 4. Showing 1 copy in chain A [auth C].

InterPro InterPro annotations
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4
  2. Fab heavy chain
  3. Fab light chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4
  2. Fab heavy chain
  3. Fab light chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4
  2. Fab heavy chain
  3. Fab light chain
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Fab heavy chain
  2. Fab light chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Fab heavy chain
  2. Fab light chain
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4
  2. Fab heavy chain
  3. Fab light chain
IPR008096
Domain description: Cytotoxic T-lymphocyte antigen 4
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Fab heavy chain
  2. Fab light chain
IPR040216
Domain description: Cytotoxic T-lymphocyte protein 4/CD28
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4

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