7syi

Electron Microscopy
4.5Å resolution

Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 3(delta dII)

Released:

Function and Biology Details

Reaction catalysed:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 36-mer (preferred)
PDBe Complex ID:
PDB-CPX-239224 (preferred)
Entry contents:
34 distinct polypeptide molecules
2 distinct RNA molecules
Macromolecules (36 distinct):
Small ribosomal subunit protein uS2 Chain: B
Molecule details ›
Chain: B
Length: 295 amino acids
Theoretical weight: 32.96 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TLT8 (Residues: 1-295; Coverage: 100%)
Gene name: RPSA
Sequence domains:
Small ribosomal subunit protein eS1 Chain: C
Molecule details ›
Chain: C
Length: 264 amino acids
Theoretical weight: 30 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SS70 (Residues: 1-264; Coverage: 100%)
Gene name: RPS3A
Sequence domains: Ribosomal S3Ae family
Large ribosomal subunit protein uL30 Chain: D
Small ribosomal subunit protein uS3 Chain: E
40S ribosomal protein S4 Chain: F
Small ribosomal subunit protein uS7 Chain: G
40S ribosomal protein S6 Chain: H
Small ribosomal subunit protein eS7 Chain: I
Small ribosomal subunit protein eS8 Chain: J
Small ribosomal subunit protein uS4 Chain: K
Small ribosomal subunit protein eS10 Chain: L
Small ribosomal subunit protein uS17 Chain: M
Small ribosomal subunit protein eS12 Chain: N
Small ribosomal subunit protein uS15 Chain: O
Small ribosomal subunit protein uS11 Chain: P
Small ribosomal subunit protein uS19 Chain: Q
Small ribosomal subunit protein uS9 Chain: R
Small ribosomal subunit protein eS17 Chain: S
Small ribosomal subunit protein uS13 Chain: T
Small ribosomal subunit protein eS19 Chain: U
Small ribosomal subunit protein uS10 Chain: V
Small ribosomal subunit protein eS21 Chain: W
Small ribosomal subunit protein uS8 Chain: X
Small ribosomal subunit protein uS12 Chain: Y
40S ribosomal protein S24 Chain: Z
Small ribosomal subunit protein eS25 Chain: a
Small ribosomal subunit protein eS26 Chain: b
Small ribosomal subunit protein eS27 Chain: c
Small ribosomal subunit protein eS28 Chain: d
Small ribosomal subunit protein uS14 Chain: e
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Chain: f
Ubiquitin-ribosomal protein eS31 fusion protein Chain: g
Small ribosomal subunit protein RACK1 Chain: h
Small ribosomal subunit protein eS32 Chain: n
18S Ribosomal RNA Chain: 2
HCV IRES Chain: z

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.5Å
Relevant EMDB volumes: EMD-25529