Function and Biology

GATOR1-RAG-RAGULATOR - Dual Complex

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: positive regulation of TORC1 signaling
Cellular component: lysosomal membrane

GO terms

Sequence families

Pfam Protein families (Pfam)
PF04670
Domain description: Gtr1/RagA G protein conserved region
Occurring in:
  1. Ras-related GTP-binding protein A
  2. Ras-related GTP-binding protein C
  3. Ras-related GTP-binding protein C
The deposited structure of PDB entry 7t3c contains 2 copies of Pfam domain PF04670 (Gtr1/RagA G protein conserved region) in Ras-related GTP-binding protein A. Showing 1 copy in chain P [auth K].
The deposited structure of PDB entry 7t3c contains 1 copy of Pfam domain PF04670 (Gtr1/RagA G protein conserved region) in Ras-related GTP-binding protein C. Showing 1 copy in chain J [auth E].
The deposited structure of PDB entry 7t3c contains 1 copy of Pfam domain PF04670 (Gtr1/RagA G protein conserved region) in Ras-related GTP-binding protein C. Showing 1 copy in chain Q [auth L].

PF16672
Domain description: Ragulator complex protein LAMTOR5
Occurring in:
  1. Ragulator complex protein LAMTOR5
The deposited structure of PDB entry 7t3c contains 2 copies of Pfam domain PF16672 (Ragulator complex protein LAMTOR5) in Ragulator complex protein LAMTOR5. Showing 1 copy in chain E [auth J].

PF08923
Domain description: Mitogen-activated protein kinase kinase 1 interacting
Occurring in:
  1. Ragulator complex protein LAMTOR3
The deposited structure of PDB entry 7t3c contains 2 copies of Pfam domain PF08923 (Mitogen-activated protein kinase kinase 1 interacting) in Ragulator complex protein LAMTOR3. Showing 1 copy in chain C [auth H].

PF03259
Domain description: Roadblock/LC7 domain
Occurring in:
  1. Ragulator complex protein LAMTOR2
The deposited structure of PDB entry 7t3c contains 2 copies of Pfam domain PF03259 (Roadblock/LC7 domain) in Ragulator complex protein LAMTOR2. Showing 1 copy in chain D [auth G].

PF15454
Domain description: Late endosomal/lysosomal adaptor and MAPK and MTOR activator
Occurring in:
  1. Ragulator complex protein LAMTOR1
The deposited structure of PDB entry 7t3c contains 2 copies of Pfam domain PF15454 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator) in Ragulator complex protein LAMTOR1. Showing 1 copy in chain O [auth M].

PF06218
Domain description: Nitrogen permease regulator 2
Occurring in:
  1. GATOR1 complex protein NPRL2
The deposited structure of PDB entry 7t3c contains 2 copies of Pfam domain PF06218 (Nitrogen permease regulator 2) in GATOR1 complex protein NPRL2. Showing 2 copies in chain A [auth B].

PF03666
Domain description: Nitrogen Permease regulator of amino acid transport activity 3
Occurring in:
  1. GATOR1 complex protein NPRL3
The deposited structure of PDB entry 7t3c contains 2 copies of Pfam domain PF03666 (Nitrogen Permease regulator of amino acid transport activity 3) in GATOR1 complex protein NPRL3. Showing 2 copies in chain H [auth C].

PF19418
Domain description: DEPDC5 protein C-terminal region
Occurring in:
  1. GATOR1 complex protein DEPDC5
The deposited structure of PDB entry 7t3c contains 1 copy of Pfam domain PF19418 (DEPDC5 protein C-terminal region) in GATOR1 complex protein DEPDC5. Showing 1 copy in chain B [auth A].

PF00610
Domain description: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Occurring in:
  1. GATOR1 complex protein DEPDC5
The deposited structure of PDB entry 7t3c contains 1 copy of Pfam domain PF00610 (Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)) in GATOR1 complex protein DEPDC5. Showing 1 copy in chain B [auth A].

PF12257
Domain description: Vacuolar membrane-associated protein Iml1, N-terminal domain
Occurring in:
  1. GATOR1 complex protein DEPDC5
The deposited structure of PDB entry 7t3c contains 1 copy of Pfam domain PF12257 (Vacuolar membrane-associated protein Iml1) in GATOR1 complex protein DEPDC5. Showing 1 copy in chain B [auth A].

PF23013
Domain description: IML1 N-terminal double psi beta barrel domain
Occurring in:
  1. GATOR1 complex protein DEPDC5

InterPro InterPro annotations
IPR024135
Domain description: Ragulator complex protein LAMTOR5
Occurring in:
  1. Ragulator complex protein LAMTOR5
IPR006762
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Ras-related GTP-binding protein A
  2. Ras-related GTP-binding protein C
  3. Ras-related GTP-binding protein C
IPR015019
Domain description: Ragulator complex protein LAMTOR3
Occurring in:
  1. Ragulator complex protein LAMTOR3
IPR004942
Domain description: Roadblock/LAMTOR2 domain
Occurring in:
  1. Ragulator complex protein LAMTOR2
IPR028209
Domain description: LAMTOR1/MEH1
Occurring in:
  1. Ragulator complex protein LAMTOR1
IPR005365
Domain description: Nitrogen permease regulator 3
Occurring in:
  1. GATOR1 complex protein NPRL3
IPR034601
Domain description: Ragulator complex protein LAMTOR4
Occurring in:
  1. Ragulator complex protein LAMTOR4
IPR037587
Domain description: Ragulator complex protein LAMTOR2-like
Occurring in:
  1. Ragulator complex protein LAMTOR2
IPR039400
Domain description: RagC/D
Occurring in:
  1. Ras-related GTP-binding protein C
  2. Ras-related GTP-binding protein C
IPR039397
Domain description: RagA/B
Occurring in:
  1. Ras-related GTP-binding protein A
IPR009348
Domain description: Nitrogen permease regulator 2-like
Occurring in:
  1. GATOR1 complex protein NPRL2
IPR000591
Domain description: DEP domain
Occurring in:
  1. GATOR1 complex protein DEPDC5
IPR027244
Domain description: Vacuolar membrane-associated protein Iml1
Occurring in:
  1. GATOR1 complex protein DEPDC5
IPR045838
Domain description: DEPDC5, C-terminal
Occurring in:
  1. GATOR1 complex protein DEPDC5
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. GATOR1 complex protein DEPDC5
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. GATOR1 complex protein DEPDC5