› 7t6u

Electron Microscopy
2.9Å resolution

Structure of the human FPR2-Gi complex with CGEN-855A

Released:
DOI: 10.2210/pdb7t6u/pdb
PDB entry 7t6u coloured by chain, front view.
PDB entry 7t6u coloured by chain, side view.
PDB entry 7t6u coloured by chain, top view.
Source organisms:
Primary publication:
Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C
OpenAccess logo Nat Commun 13 1054 (2022)
PMID: 35217703
Related structures: EMD-25728

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-210879 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 353 amino acids
Theoretical weight: 40.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: P63096 (Residues: 2-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 353 amino acids
Theoretical weight: 39.02 KDa
Source organism: Rattus
Expression system: Spodoptera
UniProt:
  • Canonical: P54311 (Residues: 2-340; Coverage: 100%)
Gene name: Gnb1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
Molecule details ›
Chain: C
Length: 67 amino acids
Theoretical weight: 7.43 KDa
Source organism: Bos taurus
Expression system: Spodoptera
UniProt:
  • Canonical: P63212 (Residues: 2-68; Coverage: 94%)
Gene name: GNG2
Sequence domains: GGL domain
B9-scFv Chain: E
Molecule details ›
Chain: E
Length: 247 amino acids
Theoretical weight: 26.32 KDa
Source organism: Rattus
Expression system: Spodoptera
Synthetic peptide Chain: L
Molecule details ›
Chain: L
Length: 8 amino acids
Theoretical weight: 1.07 KDa
Source organism: Homo
Expression system: Not provided
N-formyl peptide receptor 2 Chain: R
Molecule details ›
Chain: R
Length: 390 amino acids
Theoretical weight: 43.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: P25090 (Residues: 1-342; Coverage: 97%)
Gene names: FPR2, FPRH1, FPRL1, LXA4R
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

1 bound ligand:
Ligand PLM 2 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-25728
Expression systems:
  • Spodoptera
  • Not provided

Quick links

Citations

4 review citations

Mind the Gap-A Perspective on Strategies for Protecting against Bacterial Infections during the Period from Infection to Eradication.
Gal et al. (2023)
3 more

2 mentions without citation

Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35.
Qin et al. (2022)
1 more