› 7t79

X-ray diffraction
2.4Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152941 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 466 amino acids
Theoretical weight: 52.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 16-465; Coverage: 97%)
Gene name: GCK
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand G1S 2 x G1S
Ligand GLC 2 x GLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 84.51Å b: 102.08Å c: 130.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.254
Expression system: Escherichia coli

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