› 7t81

Electron Microscopy
10Å resolution

Model of Munc13-1 C1-C2B-MUN-C2C 2D crystal between lipid bilayers.

Released:
DOI: 10.2210/pdb7t81/pdb
PDB entry 7t81 coloured by chain, front view.
PDB entry 7t81 coloured by chain, side view.
PDB entry 7t81 coloured by chain, top view.
Source organisms:
Primary publication:
Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release.
Grushin K, Kalyana Sundaram RV, Sindelar CV, Rothman JE
OpenAccess logo Proc Natl Acad Sci U S A 119 (2022)
PMID: 35135883
Related structures: EMD-25741

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein unc-13 homolog A Chains: A, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y
Molecule details ›
Chains: A, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y
Length: 1154 amino acids
Theoretical weight: 130.9 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q62768 (Residues: 529-755, 1401-1407, 1452-1665; Coverage: 25%)
  • Canonical: Q4KUS2 (Residues: 752-1396, 1643-1712; Coverage: 42%)
Gene names: Unc13a, Unc13h1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 10Å
Relevant EMDB volumes: EMD-25741
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy.
Cui et al. (2022)
8 more