› 7t8b

Electron Microscopy
3.8Å resolution

Octameric Human Twinkle Helicase Clinical Variant W315L

Released:
DOI: 10.2210/pdb7t8b/pdb
PDB entry 7t8b coloured by chain, front view.
PDB entry 7t8b coloured by chain, side view.
PDB entry 7t8b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Riccio AA, Bouvette J, Perera L, Longley MJ, Krahn JM, Williams JG, Dutcher R, Borgnia MJ, Copeland WC
Proc Natl Acad Sci U S A 119 e2207459119 (2022)
PMID: 35914129
Related structures: EMD-25743

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188734 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Twinkle mtDNA helicase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 695 amino acids
Theoretical weight: 78.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RR1 (Residues: 1-684; Coverage: 100%)
Gene names: C10orf2, PEO1, TWNK
Sequence domains: AAA domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-25743
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structural and Molecular Basis for Mitochondrial DNA Replication and Transcription in Health and Antiviral Drug Toxicity.
Park et al. (2023)
3 other articles

2 mentions without citation

Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Riccio et al. (2022)
1 more