› 7t9m

Electron Microscopy
3.1Å resolution

Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist

Released:
DOI: 10.2210/pdb7t9m/pdb
PDB entry 7t9m coloured by chain, front view.
PDB entry 7t9m coloured by chain, side view.
PDB entry 7t9m coloured by chain, top view.
Source organisms:
Primary publication:
Autoantibody mimicry of hormone action at the thyrotropin receptor.
Faust B, Billesbølle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022)
PMID: 35940205
Related structures: EMD-25762

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225504 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
CS-17 Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 217 amino acids
Theoretical weight: 23.28 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
CS-17 Light Chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.28 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Thyrotropin receptor Chain: R
Molecule details ›
Chain: R
Length: 702 amino acids
Theoretical weight: 79.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16473 (Residues: 22-764; Coverage: 93%)
  • Best match: P16473-2 (Residues: 22-231)
Gene names: LGR3, TSHR
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Ligand NAG 2 x NAG
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-25762
Expression system: Homo sapiens

Quick links

Citations

3 review citations

G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss.
Ma et al. (2022)
2 more

1 mention without citation

Autoantibody mimicry of hormone action at the thyrotropin receptor.
Faust et al. (2022)