Function and Biology

Human Ornithine Aminotransferase (hOAT) crystallized at pH 6.0

Source organism: Homo sapiens
Biochemical function: identical protein binding
Biological process: L-proline biosynthetic process
Cellular component: mitochondrial matrix

EC 2.6.1.13: Ornithine aminotransferase

Reaction catalysed:
L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid
Systematic name:
L-ornithine:2-oxo-acid aminotransferase
Alternative Name(s):
  • GabT
  • L-ornithine 5-aminotransferase
  • L-ornithine aminotransferase
  • L-ornithine:alpha-ketoglutarate delta-aminotransferase
  • OAT
  • Ornithine 5-aminotransferase
  • Ornithine delta-transaminase
  • Ornithine ketoacid aminotransferase
  • Ornithine transaminase
  • Ornithine--2-oxoacid aminotransferase
  • Ornithine--alpha-ketoglutarate aminotransferase
  • Ornithine--keto acid aminotransferase
  • Ornithine--keto acid transaminase
  • Ornithine--ketoglutarate aminotransferase
  • Ornithine--oxo acid aminotransferase
  • Ornithine--oxo-acid transaminase
  • Ornithine:alpha-oxoglutarate transaminase

Sequence family

Pfam Protein family (Pfam)
PF00202
Domain description: Aminotransferase class-III
Occurring in:
  1. Ornithine aminotransferase, mitochondrial
The deposited structure of PDB entry 7t9z contains 3 copies of Pfam domain PF00202 (Aminotransferase class-III) in Ornithine aminotransferase, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005814
Domain description: Aminotransferase class-III
Occurring in:
  1. Ornithine aminotransferase, mitochondrial
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Ornithine aminotransferase, mitochondrial
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Ornithine aminotransferase, mitochondrial
IPR010164
Domain description: Ornithine aminotransferase
Occurring in:
  1. Ornithine aminotransferase, mitochondrial
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Ornithine aminotransferase, mitochondrial