› 7tai

Electron Microscopy
3.2Å resolution

Structure of STEAP2 in complex with ligands

Released:
DOI: 10.2210/pdb7tai/pdb
PDB entry 7tai coloured by chain, front view.
PDB entry 7tai coloured by chain, side view.
PDB entry 7tai coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2.
Chen K, Wang L, Shen J, Tsai AL, Zhou M, Wu G
Elife 12 (2023)
PMID: 37983176
Related structures: EMD-25775

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185537 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metalloreductase STEAP2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 490 amino acids
Theoretical weight: 56.12 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8NFT2 (Residues: 1-490; Coverage: 100%)
Gene names: PCANAP1, STAMP1, STEAP2, UNQ6507/PRO23203
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand FAD 3 x FAD
Ligand HEM 3 x HEM
Ligand NAP 3 x NAP
Ligand LBN 3 x LBN
Ligand CLR 6 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-25775
Expression system: Trichoplusia ni

Quick links

Citations

1 citations in other articles

STEAP2 promotes hepatocellular carcinoma progression via increased copper levels and stress-activated MAP kinase activity.
Torrez et al. (2024)