› 7taj

Electron Microscopy
2Å resolution

Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain in complex with inhibitor 11526093 (no/low occupancy-no inhibitor modeled)

Released:
DOI: 10.2210/pdb7taj/pdb
PDB entry 7taj coloured by chain, front view.
PDB entry 7taj coloured by chain, side view.
PDB entry 7taj coloured by chain, top view.
Source organism: enterovirus D68
Entry authors: Fu J, Klose T, Kuhn RJ, Center for Structural Genomics of Infectious Diseases (CSGID)
Related structures: EMD-25776

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 240-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100735 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
viral protein 1 Chain: A
Molecule details ›
Chain: A
Length: 296 amino acids
Theoretical weight: 32.82 KDa
Source organism: enterovirus D68
UniProt:
  • Canonical: A0A097BW12 (Residues: 565-860; Coverage: 14%)
Sequence domains: Picornavirus coat protein
viral protein 3 Chain: C
Molecule details ›
Chain: C
Length: 247 amino acids
Theoretical weight: 27.11 KDa
Source organism: enterovirus D68
UniProt:
  • Canonical: A0A097BW12 (Residues: 318-564; Coverage: 11%)
Sequence domains: picornavirus capsid protein
viral protein 2 Chain: B
Molecule details ›
Chain: B
Length: 238 amino acids
Theoretical weight: 26.57 KDa
Source organism: enterovirus D68
UniProt:
  • Canonical: A0A097BW12 (Residues: 79-316; Coverage: 11%)
Sequence domains: picornavirus capsid protein
viral protein 4 Chain: D
Molecule details ›
Chain: D
Length: 68 amino acids
Theoretical weight: 7.34 KDa
Source organism: enterovirus D68
UniProt: Sequence domains: Picornavirus coat protein (VP4)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2Å
Relevant EMDB volumes: EMD-25776

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